主要从事神经药理学研究，将我省道地中药材淫羊藿、金钗石斛等的有效成分用于中枢神经系统退行性变疾病，特别是阿尔茨海默病、帕金森病防治的研究已取得阶段性成果。

近年部分主持的科研项目

1.国家自然科学基金（联合基金），药理学活性筛选及机制研究——喀斯特地区特色民族医药若干基础问题研究，U1812403，2019.01-2023.12，420万元；

2.国家自然科学基金（面上），石斛碱抗衰老作用及机制研究，81773739，2018.01-2021.12，55万元；

3.国家自然科学基金（面上），基于金钗石斛生物碱调节细胞自噬的抗阿尔茨海默病机制研究，81473201，2015.1-2018.12，70万元；

4.贵州省农业重大产业科学研究攻关项目，基于贵州金钗石斛高品质特征的农业关键技术研究，黔教合K字〔2019〕016，2019.12-2020.12，105万元；

5.贵州省科技厅重大项目，贵州金钗石斛、铁皮石斛开发利用共性关键技术研究及产业化，黔科合重大专项字〔2015〕5010号，2015.01-2018.12，733万元。

主要获奖及个人荣誉

1.国务院特殊津贴专家

2.科技部“中药现代化科技产业基地建设十周年先进个人”

3.全国优秀科技工作者

4.贵州省核心专家

5.遵义市科技工作突出贡献者

6.国家科学技术进步奖二等奖

7.贵州省科学技术进步一等奖

8.贵州省科学技术进步二等奖

9.贵州省科学技术进步三等奖

10.贵州省研究生教学成果奖一等奖

学术兼职

1.中国药理学会副理事长；

2.贵州省药理学会名誉理事长。

1.Huang J, Huang N, Qiu Y, Shi J.Dendrobium nobile Lindl. alkaloid decreases Tau hyperphosphorylation via regulating PI3K/Akt/GSK-3βpathway in vitro and in vivo.J Ethnopharmacol. 2024 Mar 25:322:117592.

2.Huang Juan，Huang Nanqu，Cui Di，Shi Jingshan，Qiu Yu.Clinical antidiabetic medication used in Alzheimer's disease: From basic discovery to therapeutics development.FRONTIERS IN AGING NEUROSCIENCE.2023 Feb 10:15:1122300.

3.Huang Juan， Huang Nanqu， Mao Qianhua，Shi Jingshan，Qiu Yu.Natural bioactive compounds in Alzheimer's disease: From the perspective of type 3 diabetes mellitus.FRONTIERS IN AGING NEUROSCIENCE.2023 Mar 16:15:1130253.

4.Dai-Di Li, Chang-Qing Zheng, Feng Zhang, Jing-Shan Shi. Potential neuroprotection by Dendrobium nobile Lindl alkaloid in Alzheimer's disease models. Neural Regen Res.2022 May;17(5):972-977.

5.Hong Pan ,Fu-Guo Shi ,Chao Fang ,Jing-Shan Shi.Metabolic characterization of a potent natural neuroprotective agent dendrobine in vitro and in rats. Acta Pharmacol Sin.2022 Apr;43(4):1059-1071.

6.Tingting Pi, Guangping Lang, Bo Liu, Jingshan Shi.Protective Effects of Dendrobium nobile Lindl. Alkaloids on Alzheimer's Disease-like Symptoms Induced by High-methionine Die.Curr Neuropharmacolt .2022;20(5):983-997.

7.Archana Jain, Surendra Sarsaiya, Jishuang Chen, Qin Wu, Yuanfu Lu, Jingshan Shi.Changes in global Orchidaceae disease geographical research trends: recent incidences, distributions, treatment, and challenges.Bioengineered.2021 Dec;12(1):13-29.

8.Tingting Pi, Shenjiao Wei, Yongxuan Jiang, Jing-Shan Shi*.High Methionine Diet-Induced Alzheimer's Disease like Symptoms Are Accompanied by 5-Methylcytosine Elevated Levels in the Brain.Behav Neurol.2021 Apr 7;2021:6683318.

9.Surendra Sarsaiya, Archana Jain, Xiaokuan Fan , Qi Jia , Quan Xu, Fuxing Shu , Qinian Zhou , Jingshan Shi , Jishuang Chen. New Insights into Detection of a Dendrobine Compound From a Novel Endophytic Trichoderma longibrachiatum Strain and Its Toxicity Against Phytopathogenic Bacteria.Front Microbiol. 2020 Mar 12:11:337.

10.Surendra Sarsaiya ,Archana Jain ,Qi Jia ,Xiaokuan Fan,Fuxing Shu,Zhongwen Chen,Qinian Zhou ,Jingshan Shi,Jishuang Chen.Molecular Identification of Endophytic Fungi and Their Pathogenicity Evaluation Against Dendrobium nobile and Dendrobium officinale.Int J Mol Sci. 2020 Jan 2;21(1):316.

团队成员包括：金凤、刘波、聂晶、张玮、潘虹等