1、细胞色素P450酶的分子改造

2、不对称催化

3、手性药物的绿色合成

1、Xiao-Jian Zhou, Mao-Yao Wang, Ling Zhao, Yu-Qi He, Zhong-Qiang Wang, Jia-Jing Li, Guo-Zhong Deng, Nan-Wei Wan, and Yong-Zheng Chen^※, Enantiodivergent Synthesis of Halohydrins by Engineering P450DA Monooxygenases, ACS Catalysis, 2023, 13, 15948–15955.（IF=12.9)

2、Xiaojian Zhou; Jianqiang Zhao; Yueqin Lai; Yong You; Zhenhua Wang; Weicheng Yuan^※; Organocatalyzed asymmetric dearomative 1,3‐dipolar cycloaddition of 2‐nitrobenzofurans and N-2,2,2-trifluoroethylisatin ketimines, Chirality, 2022, 34, 1019-1034. 
3、Weicheng Yuan^※; Xiaojian Zhou; Jianqiang Zhao; Yongzheng Chen; Yong You; Zhenhua Wang; Catalytic Enantioselective Dearomatization/Rearomatization of 2-Nitroindoles to Access 3-Indolyl-3′-Aryl-/Alkyloxindoles: Application in the Formal Synthesis of Cyclotryptamine Alkaloids, Organic Letters, 2020, 22, 7088-7093.
4、Xiaojian Zhou; Jianqiang Zhao; Xinmeng Chen; Junrui Zhuo; Yanping Zhang; Yongzheng Chen;Xiaomei Zhang; Xiaoying Xu; Weicheng Yuan^※ ; Organocatalyzed Asymmetric Dearomative AzaMichael/Michael Addition Cascade of 2-Nitrobenzofurans and 2-Nitrobenzothiophenes with 2-Aminochalcones, The Journal of Organic Chemistry, 2019, 84, 4381-4391.
5、Daijun Zheng‖; Xiaojian Zhou‖; Baodong Cui; Wenyong Han; Nanwei Wan; Yongzheng Chen^※; Biocatalytic a-Oxidation of Cyclic Amines and N-Methylanilines for the Synthesis of Lactams and Formamides, ChemCatChem, 2017, 9, 937-940.（共同一作）
6、Xiaojian Zhou; Daijun Zheng; Baodong Cui; Wenyong Han; Yongzheng Chen^※; Novozyme 435 lipase mediated enantioselective kinetic resolution: a facile method for the synthesis of chiral tetrahydroquinolin-4-ol and tetrahydro-1H-benzo[b]azepin-5-ol derivatives, Tetrahedron, 2015,71, 4738-4744.