张韵，男，博士，讲师，苗族，1988年4月出生，毕业于中国科学院化学研究所，随后于德国哥廷根大学开展两年博士后研究工作。目前主要从事绿色合成及其在药物合成中的应用研究。发表SCI论文8篇，主持省部级项目3项目，作为第一导师指导学生获第八届贵州省“互联网+”大学生创新创业大赛银奖、第十三届“挑战杯” 贵州省大学生创业计划竞赛二等奖。在教学方面，主要从事《药物化学》，《有机化学》、《药学英语》等理论和实验教学工作。
仿生催化、多组分反应及其在药物合成中的应用研究
[1] Zi-Yi Yuan, Zheng-Qian Zhang, Jun-Rong Liang, Chu-Yan Lin, Dan-Li Peng, Bao-Dong Cui, Xue-Qing Mou, Yun Zhang*, Yong-Zheng Chen*. A facile one-pot synthesis of N-acyl-1-cyano-1,2,3,4-tetrahydroisoquinoline via a photoredox and Reissert-type reaction from 1,2,3,4-tetrahydroisoquinolines. New Journal of Chemistry 2023, 47, 15847.
[2] Xiaoting Chen, Zhengqian Zhang, Linyu Zhang, Yao Du, Danli Peng, Xueqing Mou, Lei Zhang*, Yongzheng Chen, Yun Zhang*. An Improved Efficient Synthesis of the Transthyretin Amyloid Fibril Inhibitors Tafamidis. Pharmaceutical Chemistry Journal 2023, 57, 725.
[3] Qi Tong, Ren-Feng Xiu, Jia-He Chen, Yun Zhang, Bao-Dong Cui, Nan-Wei Wan, Yong-Zheng Chen, Wen-Yong Han*. Toward the Generation of 2‑Amino-3-Formyl Difunctionalized Chromones via Pd-Enabled Rearrangement Strategy. ACS Catalysis 2023, 13, 12692.
[4] Xue-Qing Mou,† Min Wang,† Liang-Chen Ren, Yu-Rui Jian, Xin-Yu Fu, Hong-Yu Zheng, Xiao Zha, Bao-Dong Cui, Yun Zhang, Yong-Zheng Chen*. Photoredox-catalyzed intramolecular oxy- and aminoacylation of alkenes with acyl oxime esters: facile synthesis of acylated saturated heterocycles. Organic Chemistry Frontiers DOI: 10.1039/D3QO01659E
[5] Xue-Qing Mou, Liang-Chen Ren, Mei Zhang, Min Wang, Yu-Fan Jin, Qing-Xin Guan, Ang Cai, Shi-Min Zhang, Hai Ren, Yun Zhang, Yong-Zheng Chen*. Complementary Copper-Catalyzed and Electrochemical Aminosulfonylation of O-Homoallyl Benzimidates and N-Alkenyl Amidines with Sodium Sulfinates. Organic Letters 2022, 24, 1405.
[6] Soundararasu Senthilkumar, Guillermo Valdomir, Dhandapani Ganapathy, Yun Zhang, Lutz F. Tietze*. Enantioselective Total Synthesis of the Fungal Metabolites Blennolide D and the Enentiomers of Blennolide E and F. Organic Letters 2018, 20, 2186.
[7] Guillermo Valdomir, Soundararasu Senthilkumar, Dhandapany, Ganapathy, Yun Zhang, Lutz F. Tietze*. Enantioselective Total Syntheses of Phomopsis-H76 A and Blennolide H and Determination of Their Structure. Chemistry - A European Journal 2018, 24, 8760.
[8] Guillermo Valdomir, Soundararasu Senthilkumar, Dhandapany, Ganapathy, Yun Zhang, Lutz F. Tietze*. Enantioselective Total Synthesis of Chromanonelactone Homo- and Hetereodimers. Chemistry - An Asian Journal, 2018, 13, 1888.
[9] Yun Zhang, Yu-Fei Ao, Zhi-Tang Huang, De-Xian Wang*, Mei-Xiang Wang*, Jieping Zhu*. Chiral Phosphoric Acid Catalyzed Asymmetric Ugi Reaction by Dynamic Kinetic Resolution of the Primary Multicomponent Adduct. Angewandte Chemie International Edition. 2016, 55, 5282.
[10] 陈晓婷, 牟学清, 张磊∗, 张韵∗, 陈永正. 氯苯唑酸合成路线图解[J]. 中国药物化学杂志, 2023, 33, 397.
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